Desmin polyclonal Antibody | BS90406

Desmin polyclonal Antibody | BS90406 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, mouse, zebrafish

Application: WB ICC IHC

Application Range: WB:1:1,000-1:2,000 ICC:1:200 IHC:1:200

Background: Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. Desmin is also important in muscle cell architecture and structure since it connects many components of the cytoplasm. Finally, desmin may be important in mitochondria function. Desmin-related myopathy (DRM or Desminopathy) is a subgroup of the myofibrillar myopathy diseases and is the result of a mutation in the gene that codes for desmin which prevents it from forming protein filaments, instead forming aggregates of desmin and other proteins throughout the cell. Recently, mutations were identified in patients suffered by an arrhythmogenic right ventricular cardiomyopathy (ARVC) .

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Desmin polyclonal Antibody detects endogenous levels of Desmin protein.

Molecular Weight: 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DESM, CMD1I, CSM1, CSM2, DES, DESM, Desmin, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified

Pathway: