Desmosterol | B2784

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of Alzheimer′s disease (AD). It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation. Desmosterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of Alzheimer′s disease (AD). It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation. Desmosterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.

B2784 | Desmosterol DataSheet

Alternate Name/Synonyms: 24-dehydro Cholesterol,(3β)-cholesta-5,24-dien-3-ol

Appearance: Crystalline solid

Formulation:

CAS Number: 313-04-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₄₄O

Molecular Weight: 384.64

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~0.25 mg/ml Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Liver X receptors (LXRs) activator

MDL Number: MFCD00056432

PubChem CID: 439577

SMILES: C/C(C)=C/CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

InChi: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChi Key: AVSXSVCZWQODGV-DPAQBDIFSA-N