Description
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of Alzheimer′s disease (AD). It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation. Desmosterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of Alzheimer′s disease (AD). It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation. Desmosterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.
Alternate Name/Synonyms: 24-dehydro Cholesterol,(3β)-cholesta-5,24-dien-3-ol
Appearance: Crystalline solid
Formulation:
CAS Number: 313-04-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₄₄O
Molecular Weight: 384.64
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~0.25 mg/ml Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: Liver X receptors (LXRs) activator
MDL Number: MFCD00056432
PubChem CID: 439577
SMILES: C/C(C)=C/CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChi Key: AVSXSVCZWQODGV-DPAQBDIFSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |