DGKD Antibody (C-term) [APR15729G]

DGKD Antibody (C-term) [APR15729G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DGKD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1091 amino acids from the C-terminal region of human DGKD.

Cellular Localisation: Membrane, clathrin-coated pit. Cytoplasm

Molecular Weight: 134525

Clone: Polyclonal

Gene Name: DGKD (HGNC:2851)

Gene ID: 8527

Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095) . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) . By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity) . May also regulate clathrin-dependent endocytosis (PubMed:17880279) .

Summary: Tissue Location: [Isoform 2]: Widely expressed.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Diacylglycerol kinase delta, DAG kinase delta, 130 kDa diacylglycerol kinase, Diglyceride kinase delta, DGK-delta, DGKD, KIAA0145