Dichlorphenamide | B3272

Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Used in the treatment of glaucoma and primary periodic paralysis.

Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Used in the treatment of glaucoma and primary periodic paralysis.

B3272 | Dichlorphenamide DataSheet

Alternate Name/Synonyms: Diclofenamide 4,5-dichloro-1,3-benzenedisulfonamide

Appearance: Solid

Formulation:

CAS Number: 120-97-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₆Cl₂N₂O₄S₂

Molecular Weight: 305.16

Cell-Permeable?: True

Purity: ≥98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent carbonic anhydrase inhibitor

MDL Number: MFCD00148948

PubChem CID: 3038

SMILES: C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N

InChi: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)

InChi Key: GJQPMPFPNINLKP-UHFFFAOYSA-N