Description
Digitoxin is a lipid soluble cardiac glycoside that acts as an inhibitor of plasma membrane Na+/K+-ATPase (EC₅₀ = 0.78 µM). Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest.
Digitoxin is a lipid soluble cardiac glycoside that acts as an inhibitor of plasma membrane Na+/K+-ATPase (EC₅₀ = 0.78 µM). Digitoxin shows a significantly cytotoxic effect in H1975 cells by causing G2 phase arrest.
Alternate Name/Synonyms: 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one, Digitoxoside, Unidigin
Appearance: White to off-white solid
Formulation:
CAS Number: 71-63-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄₁H₆₄O₁₃
Molecular Weight: 764.95
Cell-Permeable?: True
Purity: ≥97%
Solubilities: ~15 mg/ml in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A lipid soluble cardiac glycoside
MDL Number: MFCD00003686
PubChem CID: 441207
SMILES: CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O
InChi: InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
InChi Key:
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
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