DIO2 Antibody (Center) [APR07583G]

DIO2 Antibody (Center) [APR07583G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids of human DIO2.

Cellular Localisation: Membrane; Single-pass membrane protein

Molecular Weight: 30552

Clone: Polyclonal

Gene Name: DIO2

Gene ID: 1734

Function: Responsible for the deiodination of T4 (3, 5, 3', 5'- tetraiodothyronine) into T3 (3, 5, 3'-triiodothyronine) . Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Summary: Tissue Location: Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050) . Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:500-2000

Synonyms: Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2