LBD
DIO2 Antibody (Center) [APR07583G]
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- LBD-APR07583G
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Description
DIO2 Antibody (Center) [APR07583G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This DIO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids of human DIO2.
Cellular Localisation: Membrane; Single-pass membrane protein
Molecular Weight: 30552
Clone: Polyclonal
Gene Name: DIO2
Gene ID: 1734
Function: Responsible for the deiodination of T4 (3, 5, 3', 5'- tetraiodothyronine) into T3 (3, 5, 3'-triiodothyronine) . Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Summary: Tissue Location: Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050) . Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:500-2000
Synonyms: Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2