Dipyridamole | B3221

Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. Formulations containing dipyridamole in combination with aspirin have been used to prevent stroke and other cardiovascular events. Apart from the well-known antiplatelet function, DIP may provide potential therapeutic benefits to patients with COVID-19.

Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. Formulations containing dipyridamole in combination with aspirin have been used to prevent stroke and other cardiovascular events. Apart from the well-known antiplatelet function, DIP may provide potential therapeutic benefits to patients with COVID-19.

B3221 | Dipyridamole DataSheet

Alternate Name/Synonyms: NSC 619103,NSC 515776,2,2’,2”,2”’-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol

Appearance: Yellow to orange crystalline powder

Formulation:

CAS Number: 58-32-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₄₀N₈O₄

Molecular Weight: 504.63

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A phosphodiesterase inhibitor and an antiplatelet agent

MDL Number: MFCD00010555

PubChem CID: 3108

SMILES: OCCN(CCO)C1=NC(N2CCCCC2)=C3C(C(N4CCCCC4)=NC(N(CCO)CCO)=N3)=N1

InChi: InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChi Key: IZEKFCXSFNUWAM-UHFFFAOYSA-N