Disulfiram | 2308

An alcohol dehydrogenase inhibitor used for the treatment of chronic alcoholism. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. Also inhibits JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone demethylase, by disruption of its Zn-binding site.

Disulfiram is an alcohol dehydrogenase inhibitor. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.

2308 | Disulfiram DataSheet

Alternate Name/Synonyms: 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane;Tetraethylthiuram disulfide; is(diethylthiocarbamyoyl)disulfide

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 97-77-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₂₀N₂S₄

Molecular Weight: 296.54

Cell-Permeable?: Yes

Purity: ≥97% by titration

Solubilities: DMSO (~ 6 mg/ml) or Ethanol (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An alcohol dehydrogenase inhibitor

MDL Number: MCFD00009048

PubChem CID: 3117

SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC

InChi: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChi Key: AUZONCFQVSMFAP-UHFFFAOYSA-N