Description
An alcohol dehydrogenase inhibitor used for the treatment of chronic alcoholism. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. Also inhibits JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone demethylase, by disruption of its Zn-binding site.
Disulfiram is an alcohol dehydrogenase inhibitor. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.
Alternate Name/Synonyms: 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane;Tetraethylthiuram disulfide; is(diethylthiocarbamyoyl)disulfide
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 97-77-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₂₀N₂S₄
Molecular Weight: 296.54
Cell-Permeable?: Yes
Purity: ≥97% by titration
Solubilities: DMSO (~ 6 mg/ml) or Ethanol (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An alcohol dehydrogenase inhibitor
MDL Number: MCFD00009048
PubChem CID: 3117
SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC
InChi: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChi Key: AUZONCFQVSMFAP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |