DLL4 Antibody (C-term) [APR11755G]

DLL4 Antibody (C-term) [APR11755G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DLL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the C-terminal region of human DLL4.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 74605

Clone: Polyclonal

Gene Name: DLL4

Gene ID: 54567

Function: Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954) . Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313) . Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity) . During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344) .

Summary: Tissue Location: Expressed in vascular endothelium.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000

Synonyms: Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4