DMGDH polyclonal Antibody | BS61706

DMGDH polyclonal Antibody | BS61706 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: DMGDH (dimethylglycine dehydrogenase), also known as ME2GLYDH or DMGDHD, is an 866 amino acid mitochondrial protein that plays a role in choline catabolism by catalyzing the demethylation of dimethylglycine to form sarcosine. Existing as a monomer that belongs to the gcvT family, DMGDH utilizes flavin adenine dinucleotide (FAD) and folate as cofactors. DMGDH is encoded by a gene that maps to human chromosome 5q14.1, defects of which are the cause of DMGDH deficiency (DMGDHD) . Patients with DMGDHD experience muscle fatigue, have a fish-like odor and excrete an elevated level of N,N-dimethylglycine (DMG) in urine.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DMGDH polyclonal Antibody detects endogenous levels of DMGDH protein.

Molecular Weight: ~ 96 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; DMGDH

Immunogen: Synthetic peptide, corresponding to amino acids 810-860 of Human DMGDH.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: