DMH-1 | 9542

DMH-1 is an analog of Dorsomorphin (Cat. No. 1686) that acts as a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH-1 exclusively targets the BMP but not the VEGF pathway. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674).

DMH-1 is an analog of Dorsomorphin (Cat. No. 1686) that acts as a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH-1 exclusively targets the BMP but not the VEGF pathway. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674).

9542 | DMH-1 DataSheet

Alternate Name/Synonyms: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Appearance: Pale orange solid

Formulation: N/A

CAS Number: 1206711-16-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₀N₄O

Molecular Weight: 380.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective BMP inhibitor

MDL Number: MFCD18384953

PubChem CID: 50997747

SMILES: CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2

InChi: InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChi Key: JMIFGARJSWXZSH-UHFFFAOYSA-N