DMXAA | 2804

DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC₅₀ = 119 and 11 µM, respectively). Recent studies have shown that DMXAA is a competitive agonist ligand for mouse.

DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC₅₀ = 119 and 11 µM, respectively). Recent studies have shown that DMXAA is a competitive agonist ligand for mouse.

2804 | DMXAA DataSheet

Alternate Name/Synonyms: 2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid; Vadimezan; ASA404

Appearance: White solid

Formulation: N/A

CAS Number: 117570-53-3

Structure Available?: yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C17H14O4

Molecular Weight: 282.29

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An apoptosis inducer and a mouse STING ligand

MDL Number: MFCD00870555

PubChem CID: 123964

SMILES: CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C

InChi: InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)

InChi Key: XGOYIMQSIKSOBS-UHFFFAOYSA-N