DNA-PKCS monoclonal Antibody | MB0134

DNA-PKCS monoclonal Antibody | MB0134 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB IP ICC

Application Range: WB: 1:1000 ICC: 1:50~100 IP: 1:50~100

Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. All of the members of the PIK-related kinases are also over 270 kDa. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of DNA-PKCS and does not cross-react with related proteins

Molecular Weight: Predicted band size:450KDa Observed band size:450KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460; PRKDC; HYRC; HYRC1

Immunogen: Recombinant full length Human DNA-PKCS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Necrotic Cell Death,Death Receptor Signaling,