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Dok-2 (R293) polyclonal Antibody | BS2637
- SKU:
- BW-BS2637
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- Usually ships in 5 working days
Description
Dok-2 (R293) polyclonal Antibody | BS2637 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse
Application: IHC IF
Application Range: IHC: 1:50~1:200 IF: 1:50~1:200
Background: Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t (9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Dok-2 (R293) polyclonal Antibody detects endogenous levels of Dok-2 protein.
Molecular Weight: ~ 56 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Docking protein 2; Downstream of tyrosine kinase 2; p56 (dok-2) ; DOK2
Immunogen: Synthetic peptide, corresponding to amino acids 271-320 of Human Dok-2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: ErbB HER Signaling,