Doxifluridine | B2650

Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

B2650 | Doxifluridine DataSheet

Alternate Name/Synonyms: Furtulon; 5'-Deoxy-5-fluorouridine; 5-fluoro-5'-deoxyuridine

Appearance: White solid

Formulation:

CAS Number: 3094-09-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₁FN₂O₅

Molecular Weight: 246.19

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >10 mg/ml in DMSO, >20 mg/ml in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An oral prodrug of the antineoplastic agent 5-fluorouracil

MDL Number: MFCD00866530

PubChem CID: 18343

SMILES: CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O

InChi: InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChi Key: ZWAOHEXOSAUJHY-ZIYNGMLESA-N