Doxorubicin HCl is loaded into PEGylated liposomes with ammonium gradient by the active loading approach. It is comparable to the commercial product DOXIL®/Caelyx® at 2.0mg/mL drug concentration. The liposomes are prepared to high quality with consistent lot-lot characteristics. Narrow particle size distribution and high drug encapsulation efficiency. Note we also carry a high drug concentration (4.0 mg/mL) version of this product (F30204B). Control liposomes for this product: F30204B-C2

Product For Research only and NOT for Human Use

Specifications

Product code: F30204B-D2

Lipid composition:  HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol)

Lipid concentration:  20.0 mM

Doxorubicin HCl:  2.0 mg/mL

Encapsulation efficiency: > 95% (typically 98%)

Loading battery:  250 mM ammonium sulfate

Mean particle size:  85 nm (80 – 90 nm)

External solution:  10% sucrose, 10 mM histidine, pH 6.5

Shelf-life: 6 months, storage: 2-8 degree C

HSPC: hydrogenated phosphatidylcholine (Soy)

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]