DP-4978 | B1288

DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras.

DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras.

B1288 | DP-4978 DataSheet

Alternate Name/Synonyms: 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea; LY3009120

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1454682-72-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₉FN6O

Molecular Weight: 424.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective pan-RAF inhibitor

MDL Number: N/A

PubChem CID: 71721540

SMILES: CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F

InChi: InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)

InChi Key: HHCBMISMPSAZBF-UHFFFAOYSA-N