Description
DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras.
DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras.
Alternate Name/Synonyms: 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea; LY3009120
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1454682-72-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₉FN6O
Molecular Weight: 424.52
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective pan-RAF inhibitor
MDL Number: N/A
PubChem CID: 71721540
SMILES: CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F
InChi: InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)
InChi Key: HHCBMISMPSAZBF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |