DPYS polyclonal Antibody | BS8162

DPYS polyclonal Antibody | BS8162 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: DPYS (dihydropyrimidinase), also known as DHPase, Hydantoinase or DHP, is a 519 amino acid protein that is expressed in liver and kidney tissue and belongs to the DHOase family. Functioning as a homotetramer, DPYS uses zinc as a cofactor to catalyze the second step of reductive pyrimidine degradation, namely the conversion of 5,6-dihydrouracil to 3-ureidopropionate. DPYS is subject to post-translational carbamylation, an event which enhances the ability of DPYS to bind zinc ions. Defects in the gene encoding DPYS are the cause of DHP deficiency, an autosomal recessive disorder that is characterized by epileptic or convulsive attacks, dysmorphic features and severe developmental delay and congenital microvillous atrophy.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DPYS polyclonal Antibody detects endogenous levels of DPYS protein.

Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dihydropyrimidinase; DHP; DHPase; Dihydropyrimidine amidohydrolase; Hydantoinase; DPYS

Immunogen: Recombinant full length Human DPYS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: