BW
DSCR1 (Phospho-S108) polyclonal Antibody | BS64573
- SKU:
- BW-BS64573
- Availability:
- Usually ships in 5 working days
Description
DSCR1 (Phospho-S108) polyclonal Antibody | BS64573 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Calcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21) .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DSCR1 (Phospho-S108) polyclonal Antibody detects endogenous levels of DSCR1 protein only when phosphorylated at Ser108.
Molecular Weight: ~ 38 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Calcipressin 1; Calcipressin1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1
Immunogen: Synthetic phosphopeptide derived from human DSCR1 around the phosphorylation site of Serine 108.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: