Description
DSM265 is a potent, selective and long duration dihydroorotate dehydrogenase (DHODH)) inhibitor (IC₅₀ = 8.9 nM). DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is highly selective towards DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates.
DSM265 is a potent, selective and long duration dihydroorotate dehydrogenase (DHODH)) inhibitor (IC₅₀ = 8.9 nM). DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is highly selective towards DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates.
Alternate Name/Synonyms: DSM-265; 2-(1,1-difluoroethyl)-5-methyl-N-(4-(pentafluoro-l6-sulfanyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Appearance: Crystalline solid
Formulation:
CAS Number: 1282041-94-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₂F₇N₅S
Molecular Weight: 415.33
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >45 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective dihydroorotate dehydrogenase (DHODH)) inhibitor
MDL Number:
PubChem CID: 51347395
SMILES: CC1=NC2=NC(=NN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F)C(C)(F)F
InChi: InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3
InChi Key: OIZSVTOIBNSVOS-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |