DUB Inhibitor, NSC-632839 | 2570

Cell-permeable. A pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.

NSC-632839 is a pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.

2570 | DUB Inhibitor, NSC-632839 DataSheet

Alternate Name/Synonyms: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 157654-67-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₁NO · HCl

Molecular Weight: 339.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~8 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A pan-specific ubiquitin isopeptidase inhibitor

MDL Number: N/A

PubChem CID: 5351362

SMILES: CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl

InChi: InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;

InChi Key: ZOKZLTXPTLIWOJ-BYCVLTJGSA-N