Description
DUSP12 Polyclonal Antibody | E-AB-14070 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: Dual specificity phosphatase 12, Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUS12, DUSP 1, DUSP 12, DUSP1, DUSP12, Serine/threonine specific protein phosphatase, TDSP4, YVH 1, YVH1, YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog, YVH1 protein tyrosine phosphatase ortholog
Application: IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Signal Transduction
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
Concentration: 0.7 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant protein of human DUSP12
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A