DUSP7 Antibody (N-term) [APR06084G]

DUSP7 Antibody (N-term) [APR06084G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DUSP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-127 amino acids from the N-terminal region of human DUSP7.

Cellular Localisation: Cytoplasm.

Molecular Weight: 44957

Clone: Polyclonal

Gene Name: DUSP7 (HGNC:3073)

Gene ID: 1849

Function: Dual specificity protein phosphatase (PubMed:9788880) . Shows high activity towards MAPK1/ERK2 (PubMed:9788880) . Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880) . In arrested oocytes, plays a role in meiotic resumption (By similarity) . Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity) . May also inactivate PRKCA and/or PRKCG (By similarity) . Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity) .

Summary: Tissue Location: Strongly expressed in liver (PubMed:8670865) . Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2