DUT polyclonal Antibody | BS7738

DUT polyclonal Antibody | BS7738 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: dUTPase (deoxyuridine 5’-triphosphate nucleotidohydrolase), also known as DUT or dUTP pyrophosphatase, is a preventive DNA repair enzyme that functions in nucleotide metabolism. dUTPase is expressed in a variety of tissues and, depending on the isoform (DUT-N or DUT-M), localizes to the nucleus or the mitochondrion. The nuclear isoform, DUT-N, is the most abundant of the two isoforms. dUTPase, in the presence of magnesium ions, is responsible for hydrolyzing dUTP to dUMP and diphosphate. This reaction is important for keeping the intracellular dUTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that dUTPase is essential for cell viability, further implying that dUTPase is a potential target for anticancer therapy. In addition, dUMP, the product of the hydrolysis reaction, is a precursor of thymidine nucleotides which are essential for DNA replication.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DUT polyclonal Antibody detects endogenous levels of DUT protein.

Molecular Weight: ~ 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Deoxyuridine triphosphatase; dut; DUT_HUMAN; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase;

Immunogen: Recombinant full length Human DUT.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: