Dutasteride | B2662

Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT. Dutasteride blocks testosterone conversion to dihydrotestosterone, and is used clinically for treating benign prostatic hyperplasia (BPH).

Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT. Dutasteride blocks testosterone conversion to dihydrotestosterone, and is used clinically for treating benign prostatic hyperplasia (BPH).

B2662 | Dutasteride DataSheet

Alternate Name/Synonyms: (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; GG-745; 17β-N-[2,5-Bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5α-androst-1-en-3-one; GI-198745

Appearance: White to of-white powder

Formulation:

CAS Number: 164656-23-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₀F₆N₂O₂

Molecular Weight: 528.53

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, dual inhibitor of 5α-reductase isoenzymes types 1 and 2

MDL Number: MFCD00937869

PubChem CID: 6918296

SMILES: CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C

InChi: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChi Key: JWJOTENAMICLJG-QWBYCMEYSA-N