Description
Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT. Dutasteride blocks testosterone conversion to dihydrotestosterone, and is used clinically for treating benign prostatic hyperplasia (BPH).
Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT. Dutasteride blocks testosterone conversion to dihydrotestosterone, and is used clinically for treating benign prostatic hyperplasia (BPH).
Alternate Name/Synonyms: (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; GG-745; 17β-N-[2,5-Bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5α-androst-1-en-3-one; GI-198745
Appearance: White to of-white powder
Formulation:
CAS Number: 164656-23-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₀F₆N₂O₂
Molecular Weight: 528.53
Cell-Permeable?: True
Purity: ≥98%
Solubilities: >30 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent, dual inhibitor of 5α-reductase isoenzymes types 1 and 2
MDL Number: MFCD00937869
PubChem CID: 6918296
SMILES: CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C
InChi: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChi Key: JWJOTENAMICLJG-QWBYCMEYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |