Dynamin-1 (phospho-S774) polyclonal Antibody | BS4228

Dynamin-1 (phospho-S774) polyclonal Antibody | BS4228 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression in testis. Both Dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the Dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to Clathrin coated pits by SH3 domain interaction with Amphiphysin, a protein highly expressed in brain.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Dynamin-1 (S774) polyclonal Antibody detects endogenous levels of Dynamin-1 protein when phosphorylated at Ser774.

Molecular Weight: ~ 98 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dynamin 1; Dynamin1; DNM1; DNM; Dynamin I; Dynamin-I; DynaminI

Immunogen: Synthetic phosphopeptide derived from human Dynamin-1 around the phosphorylation site of Serine 774.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Cell Cycle Control G1 S Checkpoint,