Dynein IC2, axonemal (N105) polyclonal Antibody | BS9405

Dynein IC2, axonemal (N105) polyclonal Antibody | BS9405 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three nonidentical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, 2 intermediate chains to anchor Dynein to its cargo, 4 smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins regulate Dynein activity, including dynactin, LIS1 and nudel (NudE-like) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Dynein IC2, axonemal (N105) polyclonal Antibody detects endogenous levels of Dynein IC2, axonemal protein.

Molecular Weight: ~ 73kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dynein intermediate chain 2, axonemal; Axonemal dynein intermediate chain 2; DNAI2

Immunogen: Synthetic peptide, corresponding to amino acids 75-135 of Human Dynein IC2, axonemal.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,T cell receptor signaling,Adherens Junction signaling,MTOR signaling,