LBD
DYRK1A Antibody (N-term) [APR11812G]
- SKU:
- LBD-APR11812G
- Availability:
- Usually ships in 5 working days
Description
DYRK1A Antibody (N-term) [APR11812G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Cellular Localisation: Nucleus. Nucleus speckle {ECO:0000250|UniProtKB:Q61214}
Molecular Weight: 85584
Clone: Polyclonal
Gene Name: DYRK1A
Gene ID: 1859
Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity) . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity) .
Summary: Tissue Location: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:500-1:2000 IHC-P--1:100~500
Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH