E-Cadherin Mouse monoclonal Antibody | MB9007

E-Cadherin Mouse monoclonal Antibody | MB9007 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human,mouse

Application: WB ICC IHC FC

Application Range: WB: 1:500-1:1000 ICC: 1:200 IHC: 1:200 FC: 1:50-1:100

Background: E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of E-Cadherin and does not cross-react with related proteins.

Molecular Weight: ~ 98, 130 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cadherin-1; Cadherin1; Cadherin 1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; CDH1; CDHE; UVO

Immunogen: This Antibody is produced by immunizing mice with recombinant protein to a region of E-cadherin.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified

Pathway: