E6005 (RVT-501) | B2263

E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for the treatment of atopic dermatitis.

E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for the treatment of atopic dermatitis.

B2263 | E6005 (RVT-501) DataSheet

Alternate Name/Synonyms: Methyl 4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate; Lotamilast

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 947620-48-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₄N₄O₅

Molecular Weight: 472.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective phosphodiesterase 4 (PDE4) inhibitor

MDL Number: N/A

PubChem CID: 24864553

SMILES: CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC

InChi: InChI=1S/C26H24N4O5/c1-27-26-29-20-14-22(34-3)21(33-2)13-19(20)23(30-26)17-6-5-7-18(12-17)28-24(31)15-8-10-16(11-9-15)25(32)35-4/h5-14H,1-4H3,(H,28,31)(H,27,29,30)

InChi Key: BBTFKAOFCSOZMB-UHFFFAOYSA-N