Description
E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for the treatment of atopic dermatitis.
E6005 (RVT 501), a selective phosphodiesterase 4 (PDE4) inhibitor, developed for the treatment of atopic dermatitis.
B2263 | E6005 (RVT-501) DataSheet
Alternate Name/Synonyms: Methyl 4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate; Lotamilast
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 947620-48-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₄N₄O₅
Molecular Weight: 472.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective phosphodiesterase 4 (PDE4) inhibitor
MDL Number: N/A
PubChem CID: 24864553
SMILES: CNC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC)OC)OC
InChi: InChI=1S/C26H24N4O5/c1-27-26-29-20-14-22(34-3)21(33-2)13-19(20)23(30-26)17-6-5-7-18(12-17)28-24(31)15-8-10-16(11-9-15)25(32)35-4/h5-14H,1-4H3,(H,28,31)(H,27,29,30)
InChi Key: BBTFKAOFCSOZMB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |