EDG1 polyclonal Antibody | BS90444

EDG1 polyclonal Antibody | BS90444 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000-1:5,000 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Background: The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA) . EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G (i/o) proteins, which activate growth related pathways

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: EDG1 polyclonal Antibody detects endogenous levels of EDG1 protein.

Molecular Weight: 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: S1P receptor 1, S1P1, S1P receptor Edg-1, S1PR1, CD363, CHEDG 1, CHEDG1, D1S3362, ECGF 1, ECGF1, EDG 1, EDG1, endothelial differentiation G protein coupled receptor 1, Endothelial differentiation G-protein coupled receptor 1, Endothelial differentiation sphingolipid G protein coupled receptor 1, FLJ58121, G protein coupled sphingolipid receptor, g protein-coupled receptor edg-1, S1P receptor 1, S1P receptor Edg 1, S1P receptor Edg-1, S1P receptor Edg1, S1P (1) receptor, S1P1, s1pr1, S1PR1, sphingolipid g-protein-coupled receptor 1, Sphingosine 1 phosphate receptor Edg 1, Sphingosine 1 phosphate receptor EDG1, sphingosine 1- phosphate receptor 1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1phosphate receptor type 1 S1P1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: