EDG2 Antibody (N-term) [APR07102G]

EDG2 Antibody (N-term) [APR07102G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This EDG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human EDG2.

Cellular Localisation: Cell surface. Cell membrane; Multi-pass membrane protein. Endosome Note=Prior to LPA treatment found predominantly at the cell surface Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment.

Molecular Weight: 41109

Clone: Polyclonal

Gene Name: LPAR1

Gene ID: 1902

Function: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040) . Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G (i) /G (o), G (12) /G (13), and G (q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040) . Signaling triggers an increase of cytoplasmic Ca (2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040) . Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1, 4, 5-trisphosphate (PubMed:19306925) . Signaling mediates activation of down-stream MAP kinases (By similarity) . Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040) . Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040) . Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity) . Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258) . Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity) .

Summary: Tissue Location: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858) Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075) . Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Lysophosphatidic acid receptor 1, LPA receptor 1, LPA-1, Lysophosphatidic acid receptor Edg-2, LPAR1, EDG2, LPA1