Edicotinib | B2382

Edicotinib is a potent and selective inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) (IC₅₀ = 3.2 nM) with potential antineoplastic activity. Displays weak affinity for KIT and FLT3 (IC₅₀ = 20 nM and 190 nM, respectively).

Edicotinib is a potent and selective inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) (IC₅₀ = 3.2 nM) with potential antineoplastic activity. Displays weak affinity for KIT and FLT3 (IC₅₀= 20 nM and 190 nM, respectively).

B2382 | Edicotinib DataSheet

Alternate Name/Synonyms: PRV 6527, 4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide, JNJ 40346527

Appearance: Crystalline solid

Formulation:

CAS Number: 1142363-52-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₇H₃₅N₅O₂

Molecular Weight: 461.61

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective CSF-1R inhibitor

MDL Number:

PubChem CID: 25230468

SMILES: CC1(CCC(=CC1)C2=C(C=CC(=N2)C3CC(OC(C3)(C)C)(C)C)NC(=O)C4=NC=C(N4)C#N)C

InChi: InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)

InChi Key: BNVPFDRNGHMRJS-UHFFFAOYSA-N