Description
Edicotinib is a potent and selective inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) (IC₅₀ = 3.2 nM) with potential antineoplastic activity. Displays weak affinity for KIT and FLT3 (IC₅₀ = 20 nM and 190 nM, respectively).
Edicotinib is a potent and selective inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) (IC₅₀ = 3.2 nM) with potential antineoplastic activity. Displays weak affinity for KIT and FLT3 (IC₅₀= 20 nM and 190 nM, respectively).
Alternate Name/Synonyms: PRV 6527, 4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide, JNJ 40346527
Appearance: Crystalline solid
Formulation:
CAS Number: 1142363-52-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₇H₃₅N₅O₂
Molecular Weight: 461.61
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective CSF-1R inhibitor
MDL Number:
PubChem CID: 25230468
SMILES: CC1(CCC(=CC1)C2=C(C=CC(=N2)C3CC(OC(C3)(C)C)(C)C)NC(=O)C4=NC=C(N4)C#N)C
InChi: InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
InChi Key: BNVPFDRNGHMRJS-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |