EDN1 Antibody (Center) [APR07643G]

EDN1 Antibody (Center) [APR07643G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This EDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the Central region of human EDN1.

Cellular Localisation: Secreted.

Molecular Weight: 24425

Clone: Polyclonal

Gene Name: EDN1

Gene ID: 1906

Function: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity) . Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031) .

Summary: Tissue Location: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, IF, FC

Dilution: WB--1:500

Synonyms: Endothelin-1, Preproendothelin-1, PPET1, Endothelin-1, ET-1, Big endothelin-1, EDN1