Eeyarestatin I | 9602

Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3 (atx3). Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the pro-apoptotic protein NOXA.

Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3 (atx3). Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the pro-apoptotic protein NOXA.

9602 | Eeyarestatin I DataSheet

Alternate Name/Synonyms: 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 412960-54-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₅Cl₂N₇O₇

Molecular Weight: 630.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway

MDL Number: MFCD00319108

PubChem CID: 23947580

SMILES: CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C

InChi: InChI=1S/C27H25Cl2N7O7/c1-27(2)24(35(40)25(38)31-19-9-5-17(28)6-10-19)34(20-11-7-18(29)8-12-20)26(39)33(27)16-22(37)32-30-15-3-4-21-13-14-23(43-21)36(41)42/h3-15,24,40H,16H2,1-2H3,(H,31,38)(H,32,37)/b4-3+,30-15+

InChi Key: JTUXTPWYZXWOIB-LWWHHIEBSA-N