Eflornithine | B2651

Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis. Eflornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis. Eflornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

B2651 | Eflornithine DataSheet

Alternate Name/Synonyms: 2-(Difluoromethyl)ornithine; dfmo; 2,5-diamino-2-(difluoromethyl)pentanoic acid; Difluoromethylornithine

Appearance: Off-white powder

Formulation:

CAS Number: 70052-12-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₂F₂N₂O₂

Molecular Weight: 182.17

Cell-Permeable?: True

Purity: ≥98%

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An irreversible inhibitor of ornithine decarboxylase (ODC)

MDL Number: MFCD00221766

PubChem CID: 3009

SMILES: C(CC(C(F)F)(C(=O)O)N)CN

InChi: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)

InChi Key: VLCYCQAOQCDTCN-UHFFFAOYSA-N