Description
Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis. Eflornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.
Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis. Eflornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.
B2651 | Eflornithine DataSheet
Alternate Name/Synonyms: 2-(Difluoromethyl)ornithine; dfmo; 2,5-diamino-2-(difluoromethyl)pentanoic acid; Difluoromethylornithine
Appearance: Off-white powder
Formulation:
CAS Number: 70052-12-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₆H₁₂F₂N₂O₂
Molecular Weight: 182.17
Cell-Permeable?: True
Purity: ≥98%
Solubilities: in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An irreversible inhibitor of ornithine decarboxylase (ODC)
MDL Number: MFCD00221766
PubChem CID: 3009
SMILES: C(CC(C(F)F)(C(=O)O)N)CN
InChi: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
InChi Key: VLCYCQAOQCDTCN-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |