EFNB1 Antibody (Center) [APG03265G]

EFNB1 Antibody (Center) [APG03265G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This EFNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human EFNB1.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=May recruit GRIP1 and GRIP2 to membrane raft domains [Ephrin-B1 intracellular domain]: Nucleus. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P52795}

Molecular Weight: 38007

Clone: Polyclonal

Gene Name: EFNB1

Gene ID: 1947

Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638) . Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638) . Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638) . Can also bind EPHB2 and EPHB3 (PubMed:8070404) . Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity) . May play a role in constraining the orientation of longitudinally projecting axons (By similarity) .

Summary: Tissue Location: Widely expressed (PubMed:8070404, PubMed:7973638) . Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638) . Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ephrin-B1, EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2, EFNB1, EFL3, EPLG2, LERK2