EGFR L858R monoclonal Antibody | MB63113

EGFR L858R monoclonal Antibody | MB63113 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: WB

Application Range: WB 1:2000

Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: epidermal growth factor receptor

Molecular Weight: 42.4 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ERBB; ERBB1; HER1; mENA; NISBD2; PIG61

Immunogen: Synthetic peptide around the L858R mutation region of the human EGFR conjugated to KLH

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A