BW
EGFRvIII (2C10) monoclonal Antibody | MB8018
- SKU:
- BW-MB8018
- Availability:
- Usually ships in 5 working days
Description
EGFRvIII (2C10) monoclonal Antibody | MB8018 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: EGFR variant III (EGFRvIII) is a truncated, constitutively active mutant form of EGFR that results from an in-frame deletion of exons 2-7. EGFRvIII is expressed in various cancers, most notably glioblastoma, where it is expressed at a frequency of 25-30%. Although complicated by the fact that it is often co-expressed with amplified EGFR, EGFRvIII is a potential therapeutic target.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: EGFR vlII mAb detects endogenous levels of EGFR vlII protein.
Molecular Weight: ~ 170 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: EGFR vIII; EGFR class lII variant; EGF Receptor vIII; EGFR variant III
Immunogen: A synthetic peptide corresponding to residues in Human EGFRvIII Peptide (LEEKKGNYVVTDHC) .
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: