Description
Elesclomol is a novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. The mechanism underlying the proapoptotic activity of elesclomol is through the induction of ROS (reactive oxygen species) and oxidative stress. Elesclomol rapidly induces ROS in cancer cells, generating a transcription profile characteristic of an oxidative stress response.
Elesclomol is a novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. The mechanism underlying the proapoptotic activity of elesclomol is through the induction of ROS (reactive oxygen species) and oxidative stress. Elesclomol rapidly induces ROS in cancer cells, generating a transcription profile characteristic of an oxidative stress response.
B1815 | Elesclomol (STA-4783) DataSheet
Alternate Name/Synonyms: N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; STA4783
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 488832-69-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₂₀N₄O₂S₂
Molecular Weight: 400.52
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO ( >20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A novel anticancer agent that displays oxidative stress induction, pro-apoptotic, and potential antineoplastic activities
MDL Number: N/A
PubChem CID: 300471
SMILES: CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2
InChi: InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
InChi Key: BKJIXTWSNXCKJH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |