ELR-510444 | 9433

ELR-510444 is a potent microtube disruptor with potential anticancer activity. It displays potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR-510444 potently inhibits cell proliferation with an IC₅₀ value of 30.9 nM in MDA-MB-231 cells, inhibits the rate and extent of purified tubulin assembly, and displaces colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.

ELR-510444 is a potent microtube disruptor with potential anticancer activity. It displays potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR-510444 potently inhibits cell proliferation with an IC₅₀ value of 30.9 nM in MDA-MB-231 cells, inhibits the rate and extent of purified tubulin assembly, and displaces colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.

9433 | ELR-510444 DataSheet

Alternate Name/Synonyms: N-​​[5-​​(5-​​cyano-​​2-​​thienyl)​-​​2-​​methylphenyl]​-​​4-​​methyl-​benzenesulfonamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1233948-35-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆N₂O₂S₂

Molecular Weight: 368.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent microtube disruptor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O

InChi: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3

InChi Key: GRYXROIHHXHFND-UHFFFAOYSA-N