ENaCδ (P446) polyclonal Antibody | BS3070

ENaCδ (P446) polyclonal Antibody | BS3070 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, α, β, γ and δ. The most frequently formed heterotetramer consists of 2α, 1β, and 1γ subunit, but the α subunit can be replaced by a δ subunit. The αENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the β and γENaC genes map to human chromosome 16p12, and the γENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle’s syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ENaCδ (P446) polyclonal Antibody detects endogenous levels of ENaCδ protein.

Molecular Weight: ~80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Amiloride-sensitive sodium channel subunit delta; Delta-NaCH; Epithelial Na (+) channel subunit delta; Delta-ENaC; ENaCD; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; DNACH

Immunogen: Synthetic peptide, corresponding to amino acids 430-480 of Human ENaCδ.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: